Wednesday, June 06, 2007

Drug Safety Information: ACE inhibitors

Okay, my first post is not specifically a drug, more like a classification of drugs. The ACE inhibitors. These are something that I keep hearing about and my dad has been on them a few times, so I decided to look into them. Here's what I found.

IMPORTANT DRUG SAFETY INFORMATION

Angiotensin Converting Enzyme (ACE) Inhibitors

GENERIC NAME: ACE inhibitor

BRAND NAMES:
captopril (Capoten), benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril) fosinopril (Monopril), ramipril (Altace), perindopril (Aceon), quinapril (Accupril), moexipril (Univasc), and trandolapril (Mavik).

SIDE EFFECTS:
One of the side effects is coughing - it may take up to a month for coughing to subside.

The most serious, but rare, side effects of ACE inhibitors are kidney failure, allergic reactions, a decrease in white blood cells, and swelling of tissues (angioedema).

HEALTH CONCERNS:
Individuals who are pregnant and those that have severe kidney problems should usually not take ACE inhibitors.

INTERACTIONS:
They have few interactions with other drugs

excessive blood potassium levels may result if ACE inhibitors are taken in conjunction with potassium supplements, salt substitutes (which often contain potassium), or other drugs that increase the body's potassium.

ACE inhibitors may increase the blood concentration of lithium (Eskalith) and lead to an increase in side effects from lithium.

WHAT THE CAREGIVER NEEDS TO KNOW:
Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen, indomethacin, and naproxen may reduce the effects of ACE inhibitors; however, there is no conclusive evidence that this interaction, if it exists, is important.

ACE inhibitors case the muscles surrounding blood vessels to relax and the blood vessels enlarge, or dilate, which reduces the blood pressure.
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SOURCES: (one or more of the following web sites may have been consulted in the research for this drug)
U.S. Food and Drug Administration
MedlinePlus
MedicineNet.com
SafeMedication.com
Wikipedia.org

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